Ginger and colorectal cancer: chemoprevention and polyp reduction

The cancer colorectal is the 3rd most common and 2nd deadliest cancer in the world. The ginger is one of the most studied food compounds in colorectal chemoprevention, with promising clinical results.

The reference clinical trial

A randomized clinical trial (Cancer Prevention Research, 2013) in patients at high risk of colorectal cancer shows that 2 g of ginger/day for 28 days :

• Reduces the colonic cell proliferation (tumor risk marker)
• Increase theapoptosis (programmed cell death) of precancerous cells
• Reduces levels of Colorectal PGE2 28% (pro-tumor prostaglandin)

Anticancer mechanisms

• Selective apoptosis : 6-gingerol and 6-shogaol induce the death of colorectal cancer cells while sparing healthy cells
• Anti-angiogenesis : blocks the formation of new vessels which nourish tumors
• Inhibition of NF-κB : major transcription factor in colorectal carcinogenesis
• Modulation of microbiome-prebiotic-digestive-science-2026">microbiome : promotes butyrate-producing bacteria, which protect the colon

Polyps and prevention

Adenomatous polyps precede 95% of colorectal cancers. Ginger reduces proliferation markers in the colonic mucosa, suggesting an effect on polyp formation and growth. In combination with the turmeric-black-pepper-synergy-benefits">turmeric (present in INTI), the chemopreventive effect is synergistic.

Sugar and colorectal cancer

Sugar and insulin resistance are recognized risk factors for colorectal cancer. NRTI with 1.19g/100ml offers the chemopreventive benefits of ginger without the glycemic risk.

Preventive protocol

• General population (>50 years) : 1-2 NRTI shots/day
• History of polyps/familial colorectal cancer : 2-3 NRTI shots/day
• This protocol does not replace screening (colonoscopy) or oncological monitoring

Conclusion

Ginger is a colorectal chemopreventive validated by clinical trials. INTI Drink — ginger + turmeric, sugar free — is a wise food supplement for colon health.