Ginger and liver : detoxification, NASH and liver protection

The ginger steatosis non-alcoholic (NASH/NAFLD) affects 25% of the world population according to Journal of Hepatology (2018). It has become the leading cause of liver disease in industrialized countries. The ginger is among the most studied plants for its liver protection.

The liver andinflammation : the NASH mechanism

NASH (Non-Alcoholic SteatoHepatitis) results from excess lipids in hepatocytes combined with turmeric-black-pepper-chronic-pain">chronic natural anti-inflammatory:

• Fat accumulation (triglycerides) in liver cells
• Activation of Kupffer cells (hepatic macrophages)
• Release of pro-inflammatory cytokines (TNF-α, IL-6)
• ginger stress oxidative via reactive oxygen species (ROS)
• Progressive fibrosis → cirrhosis → hepatocellular carcinoma

Clinical studies: ginger and NASH

Randomized controlled trial (Rahimlou et al., 2016)

Study : 44 patients with NASH, randomized into 2 groups. Treatment group: 2g/day of ginger extract for 12 weeks. Control group: placebo.

Results :

• Significant reduction in ALT and AST (liver enzymes) in the ginger group
• Improvement in insulin resistance (score ginger HOMA-IR -28%)
• Reduction in NASH activity score (NAS score)
• Decreased hepatic resistin and adiponectin

Hepatoprotective molecular mechanisms

• PPAR-α activation : [6]-gingerol activates the peroxisome proliferator-activated receptor alpha, which stimulates the beta-oxidation of fatty acids in hepatic mitochondria
• SREBP-1c inhibition : reduces de novo lipogenesis (fat synthesis by the liver)
• Induction of antioxidant enzymes : SOD, catalase, glutathione peroxidase
• Hepatic TNF-α reduction : decrease in hepatocyte apoptosis

Ginger and liver detoxification

The liver detoxifies via 2 enzymatic phases:

• Phase I (cytochromes P450): biotransformation of toxins
• Phase II (glutathione-S-transferases): conjugation and elimination

Ginger induces phase II enzymes, notably glutathione-S-transferases, increasing hepatic detoxification capacity (Young et al., 2006, Phytomedicine).

NRTI and liver health: synergy turmeric-ginger

INTI combines ginger and turmeric — two recognized hepatoprotectors:

• The curcumin inhibits NF-κB in hepatocytes and reduces hepatic fibrosis
• The piperine (black pepper) increases the bioavailability of curcumin by 2000%
• The gingerol acts synergistically on hepatic inflammation

This combination in the shot INTI offers a multi-target approach to liver protection.

Precautions

• Proven NASH requires medical monitoring and specialized dietary management.
• Ginger may interact with certain drugs metabolized by CYP3A4
• Cirrhosis or liver failure: consult a doctor before taking any supplement

INTI Drink: 1.19g sugar/100ml, organic ginger in Belgium from Peru, turmeric, lemon, black pepper, cayenne pepper, bloating-erythritol">erythritol and ginger and digestion organic. Belgium.