INTI and Cholesterol: How Sugary Drinks Raise Your Triglycerides and How INTI Helps

Sugary drinks and lipid profile: mechanisms

Fructose → Triglycerides (ChREBP pathway)

1. Fructose → Fructose-1-phosphate → Triose phosphate → Hepatic Acetyl-CoA
2. Excess Acetyl-CoA → ChREBP activated → FAS ↑ → de novo lipogenesis
3. Hepatic triglycerides → VLDL secreted → blood triglycerides ↑
4. VLDL → lipoprotein lipase → small, dense LDL (most atherogenic)
5. HDL ↓ (accelerated catabolism due to high VLDL)

Cardiovascular mechanisms of INTI

• Hepatic AMPK: gingerol → AMPK → ACC phosphorylation → malonyl-CoA ↓ → β-oxidation ↑ → de novo lipogenesis ↓ → triglycerides ↓
• Oxidized LDL ↓: gingerol + shogaol → Nrf2 → HO-1, GPx ↑ → peroxyl lipid radical scavenging → oxidized LDL ↓
• eNOS ↑: NO ↑ → inhibition of monocyte adhesion to endothelium → anti-atherosclerotic
• VCAM-1/ICAM-1 ↓: inflammation-mecanisme-cle-ginger-sugar-explanation-2026">NF-κB ↓ → endothelial adhesion molecules ↓ → less atheromatic plaque

Comparison of lipid impact: sugary drinks vs INTI