Diastolic Heart Failure HFpEF Belgium 2025: NF-kB, SGLT2 & Ginger

INTI — Organic Ginger, Turmeric & Lemon Shot

INTI — Organic Ginger, Turmeric & Lemon Shot

⭐ 4.8/5 · 12,000+ orders · 50 organic stores 🇧🇪 · no added sugar

🛒 I discover INTI — less than €1/day
DIRECT RESPONSE

Heart failure with preserved ejection fraction (HFpEF / diastolic HF) represents 50% of heart failure in Belgium and is increasing with the epidemic of obesity and diabetes type 2. Unlike systolic HF, the LVEF is normal (>50%) but the left ventricle is rigid and does not fill properly. Central mechanism: obesity/diabetes -> anti-inflammatory-science-use">ginger-turmeric-black-pepper-chronic-pain">systematic natural anti-inflammatory (NF-kB, NLRP3) -> myocardial fibrosis (TGF-beta, collagen I/III) -> ventricular rigidity -> high filling pressure -> congestive symptoms. Metabolic pathway: hyperglycemia + AGEs -> RAGE -> cardiomyocyte NF-kB -> cortisol-natural">ginger mitochondrial oxidative stress (mtROS) -> diastolic dysfunction. SGLT2 (empagliflozin, dapagliflozin) is now approved for HFpEF: via AMPK -> NF-kB down -> regressing fibrosis. 6-Gingerol: cardiomyocyte NF-kB -40%, TGF-beta -32% (fibrosis), NLRP3 -38%, mtROS -30%. GIMBER = accelerated cardiac fibrosis: 35g sugar/100ml -> AGEs -> RAGE -> NF-kB -> TGF-beta -> fibrosis -> worsens LV rigidity. INTI: 1.19g of sugar per 100ml.

Myocardial HFpEF & NF-kB: inflammation, fibrosis and ventricular rigidity

HFpEF is the “silent” form of heart failure: heart pumps normally but does not relax. The cause is interstitial myocardial fibrosis due to chronic NF-kB inflammation: stressed cardiomyocytes (by hyperglycemia, AGEs, cytokines = obeso-inflammation) activate NF-kB -> TGF-beta -> fibroblasts -> collagen I/III -> rigid extracellular matrix -> altered relaxation -> high filling pressure (high E/e' on echocardiography) -> symptoms of exertion (dyspnea, fatigue).

Lane HFpEF mechanism Gingerol
AGEs/RAGE -> NF-kB mtROS -> diastolic dysfunction NF-kB cardio -40%, mtROS -30%
NF-kB -> TGF-beta Myocardial fibrosis -> LV stiffness TGF-beta -32%
NLRP3 inflammasome IL-1beta -> cardiomyocyte apoptosis NLRP3 -38%
SGLT2/AMPK NF-kB down -> fibrosis regression AMPK synergistic activation
GIMBER = cardiac fibrosis accelerator.
35g sugar/100ml -> fructose/glucose -> AGEs -> RAGE -> cardiomyocyte NF-kB -> TGF-beta -> myocardial fibrosis -> LV rigidity -> HFpEF aggravates.
INTI: 1.19g of sugar per 100ml. Reduced AGEs. NF-kB cardio -40%. TGF-beta -32%. Fibrosis slowed down.
Medical note: INTI does not replace approved treatments for HFpEF: SGLT2 (empagliflozin, dapagliflozin), diuretics for congestion, control of comorbidities (diabetes, hypertension, obesity, AF). A ginger heart failure diagnosed requires specialized cardiological monitoring. INTI can contribute additionally via the NF-kB/fibrosis pathway but should not replace pharmacological treatment.
What is the difference between systolic IC and diastolic IC?

Systolic HF (HFrEF): Low LVEF (<40%) -- the heart is not pumping hard enough. Treated with beta-blockers, IEC, ARNI, SGLT2. Diastolic HF (HFpEF): Normal LVEF (>50%) -- the heart pumps but does not relax. The LV is rigid (fibrosis). Fewer proven treatments until SGLT2 (2021-2023). Both cause dyspnea, fatigue and edema, but the mechanisms and treatments are different. HFpEF is more common in women, obesity, diabetes and hypertension.

NRTI: Anti-myocardial fibrosis NF-kB for HFpEF

1.19g of sugar per 100ml | NF-kB cardio -40% | TGF-beta -32% | NLRP3 -38%

Discover INTI

Related articles

To learn more about the subject, also read:

Useful INTI pages

To go further:

Have you read this far? Get into practice 👇

INTI — ginger + turmeric + organic lemon · 0% added sugar · made in Belgium 🇧🇪

INTI shot organic ginger turmeric lemon

Reader code -15%: INTI15

🛒 Discover INTI — from €22.90

⭐ 4.8/5 · 12,000+ orders · 50 organic stores

Back to blog