Ginger and Cancer: Prevention, Chemotherapy, and Chemo-Induced Nausea

The ginger has been the subject of intense oncological research for 15 years. Two main angles: its in vitro/preclinical antiproliferative properties, and its clinically proven effectiveness against nausea induced by chemotherapy (CINV).

Chemotherapy nausea: the best proven indication

CINV (Chemotherapy-Induced Nausea and Vomiting) is one of the side effects the most debilitating effects of chemo. A meta-analysis of 7 randomized trials (Supportive Care in Cancer, 2020) confirms that ginger (0.5-1.5g/day) significantly reduces acute and delayed chemotherapy nausea, in addition to standard antiemetics.

Antiproliferative properties: preclinical data

Numerous in vitro studies and on animal models show that ginger compounds (6-gingerol, 6-shogaol, paradol) induce apoptosis and inhibit the proliferation of cancer cells (colon, breast, ovary, pancreas, ginger and prostate). These data are promising but do not allow us to conclude that there is an anti-cancer effect in humans — human clinical trials are underway.

Ginger and turmeric-black-pepper-chronic-pain">natural pro-cancer anti-inflammatory

Theanti-inflammatory-inflammation-natural-remedy">Chronic inflammation is a recognized risk factor for many cancers. By reducing NF-κB, COX-2 and pro-inflammatory cytokines, ginger could help reduce this background risk — to be confirmed by prospective epidemiological studies.

During chemotherapy: points of attention

Drug interactions : ginger moderately inhibits platelets. Avoid doses > 2g/day if you are taking anticoagulants (warfarin, high dose aspirin). Consult your oncologist before any supplementation during chemo.

INTI Drink: 1.19g of sugar/100ml, without preservatives, without additives. The simple formula facilitates digestive tolerance during chemo cycles. comparison INTI vs GIMBER (~34g/100ml) may worsen nausea in chemo-sensitive patients due to the sugar load.