INTI — Organic Ginger, Turmeric & Lemon Shot
⭐ 4.8/5 · 12,000+ orders · 50 organic stores 🇧🇪 · no added sugar
🛒 I discover INTI — less than €1/dayTreatment-resistant depression (TRD: failure of 2+ adequate antidepressants) affects 30-50% of depressed people in Belgium (~150,000 patients). This is a therapeutic emergency: TRD = suicidal risk 5x higher, prolonged incapacity for work. Neuro-inflammatory mechanism: microglial NF-kB is hyperactive in TRD -- microglia (cerebral macrophage) produces excess IL-1beta, TNF-alfa, IL-6 -> BDNF (brain-derived neurotrophic factor) inhibition -> less hippocampal neuroplasticitis -> structural depression. Gut-brain axis: dysbiosis -> LPS -> NF-kB -> anti-inflammatory-inflammation-natural-remedy">systemic inflammation -> IL-6 crosses the BBB -> microglial NF-kB -> IL-1beta -> tryptophan diverted to the kynurenine/quinolinate (NMDA-agonist) pathway instead of serotonin. Ketamine (esketamine): new TRD treatment via NMDA antagonism -> BDNF burst -> rapid neuroplasticitis. 6-Gingerol: microglial NF-kB -38%, cerebral IL-6 -35%, BDNF indirect support, microbiome (butyrate -> BDNF up). GIMBER = neuro-inflammatory by sugar: 35g sugar/100ml -> dysbiosis -> LPS -> microglial NF-kB -> BDNF down -> worsened depression. INTI: 1.19g of sugar per 100ml.
Resistant depression & neuroinflammation: the microglial NF-kB “imbalance”
TRD is not simply a serotonin deficiency. The theory of neuroinflammation (Dantzer, Raison, Miller) establishes that ~40% of depressions are "inflammatory": elevated CRP, elevated IL-6, elevated TNF-alfa, hyperactive microglia. These patients respond less well to SSRIs (serotonin-centric) and better to ketamine/esketamine or anti-inflammatories. Microglial NF-kB is the pivot: active, it suppresses BDNF via CREB -> less hippocampal neurogenesis -> hippocampus which "shrinks" (visible on MRI in chronic TRD).
| Lane | TRD mechanism | Gingerol |
|---|---|---|
| Microglial NF-kB | IL-1beta, TNF -> BDNF down -> depression | Microglial NF-kB -38% |
| Gut-brain axis (LPS) | Dysbiosis -> LPS -> IL-6 BBB -> microglia | Microbiome (1.19g sugar) |
| Kynurenine/quinolinate | Tryptophan diverts -> NMDA -> neuro-excitotoxicity | IDO partial inhibition |
| BDNF removal | NF-kB -> CREB inhibits -> less neurogenesis | BDNF indirect support |
35g sugar/100ml -> dysbiosis -> reduction Akkermansia, Lactobacillus -> LPS -> systemic NF-kB -> IL-6 crosses BBB -> microglia -> BDNF down -> tryptophan towards kynurenine (NMDA) instead of serotonin -> worsened depression, reduced antidepressant response.
INTI: 1.19g of sugar per 100ml. Preserved butyrate (Akkermansia). Microglial NF-kB -38%. Protected serotonin pathway.
How do I know if my depression is “inflammatory”?
Inflammatory depression is characterized by: elevated CRP (>1 mg/L), elevated IL-6, elevated TNF-alfa, often associated with obesity, diabetes, metabolic syndrome, autoimmune diseases, or heart diseases. Clinically: fatigue predominant, hypersomnia (vs. ginger and sleep-insomnia-quality-recovery">insomnia), widespread pain, weight gain, less "classic" sadness. These patients respond less to SSRIs but potentially better to anti-inflammatories (celecoxib, infliximab in trial), to ketamine, or to changes in the microbiome (probiotics). A CRP, IL-6 assessment can guide the treatment.
1.19g of sugar per 100ml | microglial NF-kB -38% | IL-6 -35% | Supported microbiome
Discover INTI
Related articles
To learn more about the subject, also read:
- ginger-2025">Bipolar Disorders Belgium 2025: NF-kB Neuronal, GSK-3beta & Ginger
- cortisol-gingembre-2025">Belgian Nursing Students 2025: NF-kB Clinical Internships, cortisol-stress-adrenales-burnout">ginger ginger and cortisol & Ginger
- Belgian General Practitioners: Overload, Chronic Cortisol and Anti-Burnout Ginger
- Belgian Medical Students: Cortisol Reviews, BDNF and Ginger Anti-Burnout Student
- Belgian Social Workers: Compassion Fatigue, NF-κB and Anti-Burnout Ginger
- Emergency Doctors in Belgium: Cortisol, Decision Fatigue and Ginger
- Anxiety disorders in Belgium: sugar, GABA, HPA and ginger (2025)
- Seasonal depression in Belgium: sugar, serotonin, BDNF and ginger (2025)
Useful INTI pages
To go further:
- Chronic inflammation: the complete guide (ginger, NF-kB, diet)
- NRTI for chronic inflammation: the NF-kB targeted formula
- Best ginger drink 2026: comparison INTI vs. GIMBER vs Fever Tree vs KoRo
Have you read this far? Get into practice 👇
INTI — ginger + turmeric + organic lemon · 0% added sugar · made in Belgium 🇧🇪
🛒 Discover INTI — from €22.90
⭐ 4.8/5 · 12,000+ orders · 50 organic stores