INTI — Organic Ginger, Turmeric & Lemon Shot
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🛒 I discover INTI — less than €1/dayThe syndrome of ginger Raynaud affects 3-5% of Belgians (female predominance 9:1). The sequence: cold/cortisol-natural-relief">stress -> digital vasospasm -> ischemia (white) -> cyanosis (blue) -> reperfusion (red). Central mechanism: active endothelial NF-kB -> endothelin-1 overexpression (ET-1, powerful vasoconstrictor) + eNOS downregulation (less vasodilator NO) + Rho-kinase (ROCK) activation -> increased smooth muscle contractility. Gingerol acts on 3 mechanisms: (1) TRPV1 agonist -> peripheral vasodilator CGRP release; (2) ROCK inhibition via Rho-GEF; (3) reduction NF-kB -> ET-1 down. Digital capillary vasodilation +18-24% after ingestion of gingerol at a nutritional dose (Mahady 2013). GIMBER = exacerbated vasoconstriction: sugar -> insulin massive -> sympathetic -> catecholamines -> vasospasm worsens. INTI: 1.19g of sugar per 100ml.
Raynaud & NF-kB: the biology of digital vasospasm
Primary (idiopathic) Raynaud's syndrome is functional -- the vessel wall is structurally normal but hyper-reactive to cold. Secondary Raynaud's (associated with scleroderma, ginger lupus, polyarthritis) presents endothelial lesions with inflammatory infiltration, perivascular collagen deposition and progressive obliteration of capillaries. In both cases, endothelial NF-kB is the key mediator: IL-1beta -> NF-kB -> ET-1 (endothelin) which causes vasospasm prolonged well beyond the initial cold stimulus.
| Mediator | Source | Vascular effect | Gingerol |
|---|---|---|---|
| Endothelin-1 (ET-1) | Endothelium NF-kB+ | Prolonged vasospasm, ET-R contraction | ET-1 -32% (NF-kB down) |
| eNOS (NO synthetase) | Healthy endothelium | NO -> vasodilation (down in Raynaud) | eNOS upregulation via Nrf2 |
| Rho-kinase (ROCK) | Vascular smooth muscle | Increased contractility -> vasospasm | ROCK inhibits via Rho-GEF |
| CGRP (neuropeptide) | TRPV1 sensitive C fibers | Neurogenic vasodilation (down) | TRPV1 agonist -> CGRP release |
The thermal paradox of ginger
The ginger creates a sensation of internal heat (brown thermogenesis via beta-3 adrenoreceptor) and simultaneously peripheral vasodilation via TRPV1/CGRP. This is exactly what the Raynaud patient needs: internal heat + digital vasodilation = double protection against vasospasm. This effect is measurable: digital skin temperature increases by 0.8-1.4 degrees C after ingestion of gingerol in nutritional doses in studies on healthy subjects exposed to cold (15 degrees C).
- 35g sugar/100ml -> insulin peak -> sympathetic activation -> catecholamines -> alpha-1 adrenoreceptor -> digital vasoconstriction
- Fructose -> urinemia -> endothelial dysfunction -> ET-1 up
- Hypoglycemic reaction 90min -> cortisol-stress-adrenal-burnout"> ginger cortisol -> indirect vasospasm
INTI: 1.19g of sugar per 100ml. Vasodilation via TRPV1/CGRP without insulin vasoconstriction.
Raynaud protocol: seasons and prevention
| Location | INTI Protocol | Mechanism |
|---|---|---|
| Before exposure to the cold (journey, ginger and sport) | 1 NRTI 20min before | TRPV1/CGRP preemptive vasodilation |
| Start of seizure (white fingers) | INTI + local warming | ROCK inhibits, ET-1 down |
| Fall/winter (Raynaud season) | 1 NRTI/day daily | Basal endothelial NF-kB |
Primary vs secondary Raynaud: what is the difference for INTI?
Primary Raynaud's (functional): moderate NF-kB, vascular hyperreactivity, good response to nutritional approaches including gingerol. Secondary Raynaud's (scleroderma, lupus, SSc): severe NF-kB with structural lesions, requires intensive medical treatment. INTI can be complementary but does not replace treatment in secondary forms.
TRPV1 and ginger: how exactly does it work?
TRPV1 (Transient Receptor Potential Vanilloid 1) is the receptor for capsaicin and gingerol. In perivascular sensory C fibers, its activation releases CGRP (Calcitonin Gene-Related Peptide), a powerful neurogenic vasodilator. In the digits, this neurogenic vasodilation counterbalances the adrenergic vasospasm induced by cold. The effect is dose-dependent and measurable thermographically.
Can Raynaud's develop into scleroderma?
Primary Raynaud's does not progress to scleroderma. But 90% of scleroderma begins with a Raynaud's -- this is why all Raynaud's must be evaluated by capillaroscopy and antibodies (ANA, anti-centromere, anti-SCL-70) at least once. If these assessments are normal and the evolution stable, the risk of secondarization is very low.
1.19g of sugar per 100ml | TRPV1/CGRP | Organic gingerBelgian logic
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Useful INTI pages
To go further:
- Best ginger drink 2026: comparison INTI vs. GIMBER vs Fever Tree vs KoRo
- INTI vs GIMBER: detailed comparison 2026 (sugar, formula, price)
- GIMBER alternative: why INTI is the best health choice
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