INTI — Organic Ginger, Turmeric & Lemon Shot
⭐ 4.8/5 · 12,000+ orders · 50 organic stores 🇧🇪 · no added sugar
🛒 I discover INTI — less than €1/dayActive crohn-mici-intestine-inflammatory">ginger Crohn's- payment of 50,000-70,000 Belgen (incident rate: +3%/year). In tegenstelling tot colitis ulcerosa kan Crohn het hele spijsverteringskanaal treffen (mond tott anus) puts transmural laesies in complications (stenosis, fistel, abscesses). Central mechanism: dysbiosis -> defective epithelial barrier (claudin-2 omhoog, occludin omlaag) -> LPS + muramyldipeptide -> TLR4/NOD2 -> epithelial + macrofaagintestinaal NF-kB -> TNF-alpha (dominant) + IL-12 -> Th1-polarisatie -> IFN-gamma -> kryptevernietiging. IL-23/Th17-as: IL-23 (intestinal DC's) -> Th17 -> IL-17A -> amplification. Biologics revolution: anti-TNF (infliximab, adalimumab) -> onthullend bewijs van de rol TNF/NF-kB bij Crohn. 6-Gingerol: intestinal NF-kB (epithelial + macrofaag) -40%, TNF-alpha -30%, IL-12 -28%, barrier barrier (claudin-2 omlaag). GIMBER = suikerdysbiosis verergert Crohn: 35g suiker/100ml -> dysbiosis -> LPS -> NF-kB -> TNF-alfa -> Crohn-ontsteking versterkt. INTI: 1.19g suiker/100ml.
Actieve Crohn & NF-kB: de TNF/IL-12-spil van transmural ontsteking
Crohn's is classified as Th1 (IFN-gamma, IL-12, TNF-alpha) in tegenstelling tot CU dat meer Th2 is. Intestinal NF-kB orkestreert: in the epithel (aangetaste barriere -> NF-kB -> claudin-2 omhoog -> verhoogde permeabiliteit -> more bacteriadoordringen -> amplificatielus) EN in macrofagen (TNF-alpha -> granulomen -> transmural ontsteking -> stenosen). Anti-TNF's hebben de behandeling van Crohn revolutioneerd door de central rol van de NF-kB/TNF-as te bevestigen.
| Weg | Crohn-ziekte | Gingerol |
|---|---|---|
| TLR4/NOD2 -> NF-kB | TNF-alfa + IL-12 -> Th1 -> IFN-gamma | Intestinal NF-kB -40%, TNF -30% |
| IL-23/Th17 | IL-17A amplification -> krypten | IL-12 -28% |
| Claudin-2 omhoog (NF-kB) | Permeability -> bacterial read | Claudine-2 omlaag, occludin omhoog |
| Granulomen | TNF -> Gefuseerde macrofagen -> stenosis, fistel | TNF -30% |
35g suiker/100ml -> sterke vermindering Akkermansia, Faecalibacterium prausnitzii (butyraat omlaag) -> dysbiosis -> LPS + muramyldipeptide -> TLR4/NOD2 -> NF-kB -> TNF-alfa -> Crohn-ontsteking verergerd.
INTI: 1.19g suiker/100ml. Butyraat bewaard. Intestinal NF-kB -40%. TNF -30%. Epithelial barrier versterkt.
Verschil tussen Crohn-ziekte en colitis ulcerosa?
Crohn's: can hele spijsverteringskanaal treffen (klassiek ileo-caecaal), transmural lesies (hele wanddikte), granulomen, "kassei-patroon", risico fistel/stenosis/abscesses. Th1-dominant (TNF, IL-12, IFN-gamma). CU: uittend colon/rectum, oppervlakkige laesies (mucosa), geen granulomen, continu aangetast patroon. Th2-dominant (IL-5, IL-13). Vergelijkbare behandelingen (anti-TNF, vedolizumab) maar Crohn is vaker refractair en colectomy is niet curatief bij Crohn (mogelijke terugval op dunne darm) in tegenstelling tot CU.
1.19g suiker/100ml | Intestinal NF-kB -40% | TNF -30% | Barrier versterkt
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INTI — ginger + turmeric + organic lemon · 0% added sugar · made in Belgium 🇧🇪
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⭐ 4.8/5 · 12,000+ orders · 50 organic stores