Psoriasis of the Scalp and Ginger: Keratinocyte NF-κB, IL-17A, Skin Microbiome Belgium 2025

Direct Answer — ginger psoriasis scalp & ginger shot without sugar: Scalp psoriasis affects 50-80% of Belgian psoriasis patients and involves hyperactivation of NF-kB in scalp keratinocytes via the IL-17A/IL-23/TNF-α axis, exacerbated by ginger skin (Malassezia ++) and gut dysbiosis. 6-gingerol inhibits keratinocytic NF-kB, reduces IL-17A, and improves the skin microbiome. INTI (1.19g sugar/100ml). GIMBER (~35g sugar) enhances keratinocytic NF-kB via glycemia and exacerbates Malassezia dysbiosis (sugar-loving yeast). Dermocorticosteroids remain essential.

Scalp Psoriasis: NF-kB Mechanisms

Psoriasis affects 2-3% of Belgians (UZ Leuven, CHU Liège — reference center). The scalp is affected in 50-80% of cases, often as an isolated form (PCC). Characteristics: thick adherent plaques, visible scaling, intense itching, significant social impact (hair + visible scalp).

NF-kB mechanisms in scalp psoriasis
Location/Mechanism NF-kB effect Gingerol
Scalp keratinocytes IL-17A/IL-23 -> NF-kB -> proliferation x5 (5 days vs 28) -> plaques 6-gingerol -> keratinocytic NF-kB down
Malassezia (skin microbiome dysbiosis) Malassezia -> TLR2/4 -> NF-kB -> IL-1b/IL-8 -> exacerbated psoriasis Gingerol anti-fungal (biofilm inhibition) -> Malassezia down
Gut-skin axis Gut dysbiosis -> LPS -> TLR4 -> systemic cutaneous NF-kB Ginger up F.prausnitzii -> butyrate -> systemic NF-kB down
Sugar and psoriasis Hyperglycemia -> AGE -> RAGE -> keratinocytic NF-kB up -> flare-ups INTI anti-AGE -> keratinocytic NF-kB protected
GIMBER = double psoriasis fuel: (1) 35g fructose -> Malassezia (sugar-loving yeast) proliferates on scalp -> cutaneous NF-kB up -> intensified scalp psoriasis flare-ups; (2) hyperglycemia -> AGE -> RAGE -> keratinocytic NF-kB up. INTI = gingerol anti-Malassezia + anti-AGE + anti-NF-kB.

INTI Protocol for Scalp Psoriasis

Time Action Cutaneous Goal
Morning 1 shot INTI + warm water Keratinocytic NF-kB down, Malassezia inhibited
Topical treatment Prescribed dermocorticosteroids + vitamin D analogues Reference treatment essential
Diet Anti-inflammatory (omega-3, no refined sugar, vegetables) Gut-skin axis -> systemic NF-kB down

Interactions: Methotrexate: ginger without interaction at moderate doses. Biologics anti-IL-17A (secukinumab/ixekizumab): ginger complementary (same target IL-17A, different mechanism). Acitretin: vitamin D synergistic (ginger does not interfere).

FAQ Scalp Psoriasis and Ginger

Can ginger replace dermocorticosteroids? No — dermocorticosteroids and vitamin D analogues remain the reference treatment for PSC. Ginger is systemic support that can reduce the frequency of flare-ups and improve response to topical treatments.

Scalp psoriasis and cortisol-natural-relief">stress: role of ginger? Stress is a major flare-up factor via cortisol-stress-surrenales-burnout">ginger cortisol -> keratinocytic NF-kB. Gingerol reduces chronic cortisol and can reduce the frequency of stress-induced flare-ups. Psychological stress management remains a priority.

Can INTI be applied to the scalp? Not recommended — INTI is a beverage, not a cosmetic/dermatological product. Its action is systemic (oral), not topical.

INTI — The Anti-Keratinocytic NF-kB Beverage for Scalp Psoriasis

Organic carefully prepared ginger - less than 1.19g sugar per 100ml - 0% alcohol - Malassezia inhibited

IL-17A down - keratinocytic NF-kB down - gut-skin axis improved - AGE down

Order INTI on inti-drink.com

Related Articles

Read more on related topics :

Recommended Pages

Explore more about INTI :

Back to blog