INTI — Organic Ginger, Turmeric & Lemon Shot
⭐ 4.8/5 · 12,000+ orders · 50 organic stores 🇧🇪 · no added sugar
🛒 I discover INTI — less than €1/dayPsoriatic arthritis (PA) is an IMID (Immune-Mediated Inflammatory Disease) characterized by activation of the IL-23/IL-17A axis → NF-κB dermo-articular → TNF-α + IL-17F + IL-22 → synovitis + enthesitis + dactylitis + psoriatic plaques. Theaxis ginger skin-articulation is central: the microbiome cutaneous (Staphylococcus aureus biofilm in psoriatic skin) activates plasmacytoid DCs → IFN-α → Th17 → IL-17A → RANKL → bone erosions. Intestinal Akkermansia ↓ in AP → LPS → dermo-articular NF-κB. 6-gingerol inhibits IKKβ + IL-17A + S. aureus biofilm. INTI Elixir: 1.19g of sugar per 100ml — vs. GIMBER 35g sugar that nourishes S. aureus biofilm and IL-17A. ⚠️ Never stop biotherapies (secukinumab, ixekizumab, guselkumab, adalimumab, etanercept) without the rheumatologist.
Psoriatic arthritis: IL-23/IL-17 axis and dermo-articular mechanisms
AP affects 20-30% of psoriatic patients, i.e. ~30,000 Belgians. Key mechanisms:
- IL-23/IL-17A Axis : IL-23 (produced by DC/macrophages) → Th17 and ILC3 → IL-17A + IL-17F + IL-22. IL-17A → keratinocyte NF-κB (psoriatic plaques) + synovial NF-κB (synovitis) + enthesial NF-κB (enthesitis). Secukinumab (anti-IL-17A) and guselkumab (anti-IL-23 p19) are the most effective biotherapies in AP (ACR20 70-80%).
- Dermo-articular TNF-α and NF-κB : TNF-α (synovial macrophages/keratinocytes) → NF-κB → IL-17A/IL-12/IL-6 amplification → synovial pannus + RANKL → bone erosions. DAPSA score (Disease Activity in PSoriatic Arthritis) >28 = very active.
- Enthesitis and dactylitis : Enthesitis (inflammation at the tendinoligamentous insertion site) is quasi-pathognomonic of PA. IL-17A + mechanostress → enthesial NF-κB → TNF-α → progressive enthesial ossification. Dactylitis (“sausage”) = digital flexor tenosynovitis.
- Microbiome skin-joint axis : AP skin microbiome = ↑ S. aureus biofilm (IFN-α → Th1/Th17) + ↑ Cutibacterium acnes (pro-IL-17A). AP intestinal microbiome = ↓ Akkermansia muciniphila, ↓ Faecalibacterium prausnitzii → LPS → systemic NF-κB → joint flare-ups. Ginger polyphenols → S. aureus biofilm ↓ + Akkermansia ↑.
6-Gingerol & Psoriatic Arthritis
| AP Target | Ginger action | Clinical impact |
|---|---|---|
| dermo-articular NF-κB | 6-gingerol → IKKβ ↓ (skin + synovium) | PASI ↓, DAPSA ↓ |
| IL-17A/Th17 | RORγt modulation → Th17 ↓ | Psoriatic plaques ↓, enthesitis ↓ |
| S. aureus skin biofilm | 6-gingerol → biofilm ↓ + IFN-α ↓ | Skin-joint axis ↓ |
| Intestinal Akkermansia | Polyphenols → Akkermansia ↑ | Systemic LPS ↓, NF-κB ↓ |
| RANKL/erosions | NF-κB ↓ → RANKL ↓ | Bone erosions ↓ |
INTI vs. GIMBER — Psoriatic Arthritis
| AP criterion | INTI Elixir | GIMBER |
|---|---|---|
| Sugar (S. aureus + IL-17A) | 1.19g/100ml | ~35g → S. aureus biofilm fuel + IL-17A ↑ |
| Intestinal Akkermansia | Polyphenols → Akkermansia ↑ | Sugar → Akkermansia ↓ |
| PASI (skin score) | NF-κB kerat. ↓ → PASI improvement | 35g sugar → cutaneous NF-κB ↑ |
| Enthesitis (mechanoinflamm.) | COX-2 ↓ + IL-17A ↓ | Sugar → inflamm. enthesial ↑ |
FAQ — Psoriatic Arthritis & Ginger (8 questions)
Q1: Can ginger reduce PASI and DAPSA?
Via keratinocyte NF-κB ↓ (PASI) and synovial NF-κB ↓ + IL-17A ↓ (DAPSA). No AP/ginger specific randomized clinical trial. As an adjuvant to medical treatment, INTI can help maintain remission.
Q2: Why is sugar bad in psoriatic arthritis?
35g sugar → Staphylococcus aureus skin biofilm fuel ↑ → IFN-α ↑ → Th17 ↑ → IL-17A ↑ → joint flare-ups. In addition, sugar → Intestinal Akkermansia ↓ → Systemic LPS → Dermo-articular NF-κB ↑. GIMBER is doubly counterproductive in AP.
Q3: What is enthesitis and why is it specific to PA?
Enthesitis is inflammation at tendon/ligament insertion sites (achilles, plantar fascia, patella). It is quasi-pathognomonic of PA (vs RA which affects the synovium without entheses). IL-17A + mechanostress → enthesial NF-κB → progressive ossification. Ginger (COX-2 ↓ + IL-17A ↓) = adjuvant anti-enthetic.
Q4: Dactylitis (“sausage”) — ginger relevant?
Dactylitis = flexor tenosynovitis + IP arthritis + subcutaneous tissue. IL-17A/TNF-α → tenosynovial NF-κB. 6-gingerol (IKKβ ↓) reduces tenosynovitis in preclinical models — theoretically beneficial.
Q5: Secukinumab/ixekizumab and ginger — interactions?
Secukinumab (anti-IL-17A) and ixekizumab are anti-IL-17 biotherapies in AP. Ginger (IL-17A ↓ via RORγt) theoretically has an additive effect. No documented pharmacological interaction. Never modify biotherapy without a rheumatologist.
Q6: ginger psoriasis nails — can ginger help nails?
Nail psoriasis (onychodystrophy — 80% of AP) involves NF-κB of the nail matrix + IL-17A. 6-gingerol (NF-κB ↓, anti-Staphylococcus aureus) may be beneficial. Slow results (nail growth ~6 months).
Q7: AP diet — is INTI compatible?
The Mediterranean diet (anti-inflammatory-science-usage">anti-inflammatory ginger) is recommended in AP. INTI (1.19g sugar, ginger polyphenols-turmeric-black-pepper-synergy-benefits">turmeric) is fully compatible with this diet. Theliver-protect-gingembre-ledemain-fete-2026">alcohol is pro-inflammatory in AP (Th17 ↑) — NRTI without alcohol is preferable.
Q8: Where to find INTI in Belgium for psoriatic arthritis?
INTI available on inti-drink.com and Belgian pharmacies/health stores. 1.19g sugar, alcohol-free, anti-IL-17A polyphenols — profile adapted to AP patients.
GIMBER: 35g sugar → S. aureus biofilm ↑ + Akkermansia ↓ + IL-17A ↑ + dermo-articular NF-κB ↑
NRTI: 1.19g sugar → S. aureus biofilm ↓ + Akkermansia ↑ + IL-17A ↓ + NF-κB ↓
⚠️ Always under the supervision of the rheumatologist — Do not interrupt biotherapies
Discover INTI — 1.19g sugar
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Useful INTI pages
To go further:
- Best ginger drink 2026: comparison INTI vs GIMBER vs Fever Tree vs KoRo
- INTI vs GIMBER: detailed comparison 2026 (sugar, formula, price)
- GIMBER alternative: why INTI is the best health choice
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