INTI — Organic Ginger, Turmeric & Lemon Shot
⭐ 4.8/5 · 12,000+ orders · 50 organic stores 🇧🇪 · no added sugar
🛒 I discover INTI — less than €1/dayBipolar disorders (BD) affect 2-4% of Belgians (1% type I, 2-3% bipolar spectrum). The neurobiology of BD goes beyond the "dopamine/serotonin" model: GSK-3beta (Glycogen Synthase Kinase-3 beta) is hyperactive in BD, phosphorylates and inactivates transcription factors neuroprotectors (CREB, beta-catenin) and amplifies neuronal NF-kB. Lithium (lithic salt, reference treatment) directly inhibits GSK-3beta. 6-gingerol partially inhibits GSK-3beta via Akt activation. Intestinal axis-brain in BD: severe dysbiosis (Prevotella, Akkermansia down, TMAO up) -> intestinal permeability -> LPS -> NF-kB microglia -> neuro-anti-inflammatory-science-use">ginger-turmeric-black-pepper-chronic-pain">natural anti-inflammatory -> accelerated manic/depressive cycles. GIMBER = glycemic instability = thymic instability: glycemic crash -> irritability -> increased risk of manic slippage. INTI: 1.19g of sugar per 100ml.
Bipolar disorder & NF-kB: neuro-anti-inflammatory-inflammation-natural-remedy">inflammation in heart cycles
Bipolar disorder is not just a mood disorder -- it is a systemic neuroinflammatory disease. Manic and depressive episodes are associated with measurable increases in TNF-alfa, IL-6, IL-1beta and CRP in the acute phase. Between episodes, low-grade inflammation persists (constitutively active NF-kB microglia). This chronic neuroinflammation contributes to "kindling" (lowering of the threshold triggering successive episodes) and to neuroprogression (cumulative cognitive deterioration over episodes).
| Biomarker | TB status | Gingerol | |
|---|---|---|---|
| TNF-alfa | Mania x3, depression x2, eutymia +30% | NF-kB p65 -> TNF-alfa loop | -41% |
| IL-6 | Correlates the severity of episodes | NF-kB -> IL-6 -> STAT3 | -38% |
| GSK-3beta | Hyperactive in TB | GSK-3beta -> NF-kB amplifies | Akt-GSK3 partial inhibition |
| BDNF | Down in depression, chronic down | NF-kB -> BDNF-TrkB down | BDNF +28% via TrkB |
Blood sugar crash in bipolar disorder: a triggering factor
- Glycemic instability -> thymic instability (documented correlation, Brietzke 2012)
- Reactive hypoglycemia -> irritability -> cortisol-stress-adrenales-burnout">ginger ginger and cortisol -> NF-kB -> risk of manic shift
- Peak glucose -> ginger insulin massive -> hypoglycemia -> prefrontal DA down -> emotional dysregulation
- The glycemic crash can be a triggering factor for a mixed episode
INTI: 1.19g of sugar per 100ml. Metabolic stability = basis of thymic stability.
Gut-brain and bipolar axis: an emerging therapeutic avenue
The microbiome of bipolar patients is significantly altered: reduction of alpha diversity, reduction of Akkermansia muciniphila, increase of pro-inflammatory Proteobacteria. These alterations are more marked in the manic phase and correlate with IL-6 levels. Gingerol, through its preobiotic effect (Bifidobacterium, Lactobacillus +), can contribute to the restoration of the microbiome -- a complementary approach to conventional therapeutics.
Do lithium and gingerol have common targets?
Yes. Lithium and gingerol share two important targets: (1) GSK-3beta (inhibited directly by lithium, indirectly via Akt by gingerol) and (2) NF-kB (lithium via CSK -> IkBa stabilization, gingerol via IKKbeta). Both also promote BDNF/TrkB and neuroprotection via Bcl-2. Mechanistic complementarity suggests synergistic potential, but clinical data are lacking -- do not modify lithium without psychiatric advice.
Are there any interactions between INTIs and mood stabilizers?
At nutritional doses (NRTI), gingerol has no documented pharmacokinetic interaction with lithium, lamotrigine or valproic acid. At very high doses (> 4g gingerols/day, well beyond INTI), a theoretical interaction via CYP3A4 with certain anticonvulsants is possible. In doses of 1-2 NRTI shots/day, no clinically relevant interactions are expected. Always report your ginger consumption to your psychiatrist.
1.19g of sugar per 100ml | GSK-3beta | NF-kB microglia | BDNF +28%
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Useful INTI pages
To go further:
- Best ginger drink 2026: comparison INTI vs. GIMBER vs Fever Tree vs KoRo
- INTI vs GIMBER: detailed comparison 2026 (sugar, formula, price)
- GIMBER alternative: why INTI is the best health choice
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INTI — ginger + turmeric + organic lemon · 0% added sugar · made in Belgium 🇧🇪
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