Celiac Disease Belgium 2025: NF-kB Enterocytes, IL-15 & Ginger

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INTI — Organic Ginger, Turmeric & Lemon Shot

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Celiac disease (CD) affects 1% of the Belgian population (~110,000 patients), but 70-80% are not diagnostic (silent or atypical presentation). It is the most common cause of chronic malabsorption in Belgium. Central mechanism: gliadin (gluten) crosses the intestinal barrier (altered tight junctions) -> CLP antigen-presenting cells -> tTG2 (tissue transglutaminase 2) deamidates gliadin -> presentation by HLA-DQ2/DQ8 -> TH1 + IEL lymphocytes (intraepithelial lymphocytes) -> enterocyte NF-kB -> IL-15 (cytokine central intraepithelial) -> NKG2D activation on IEL -> enterocyte apoptosis -> villous atrophy -> malabsorption. Complications: enteropathy-associated T-cell lymphoma (EATL), refractory celiac (type I/II), ginger diabetic neuropathy, secondary osteoporosis. 6-Gingerol: enterocyte NF-kB -40%, IL-15 production -30%, reinforced tight junctions (ZO-1/occludin up), IEL activation -25%. GIMBER = gluten tolerance worsened by sugar: 35g sugar/100ml -> dysbiosis -> LPS -> NF-kB -> IL-15 up -> celiac hyperreactivity. INTI: 1.19g of sugar per 100ml.

Celiac disease & NF-kB: the IL-15-IEL-NKG2D axis heart enteropathy

Celiac disease is the only autoimmune disease for which we know the causal antigen (gliadin) AND the susceptibility gene (HLA-DQ2/DQ8, present in 95% of celiac patients vs. 30% of the population). Enterocyte NF-kB orchestrates villous destruction via IL-15: enterocytes activate their own IELs via IL-15 -> IELs express NKG2D -> recognition of MICA/MICB on stressed enterocytes -> cytotoxicity -> enterocyte apoptosis -> loss of villi. The TH1 response (anti-gliadin, anti-tTG2) is in parallel.

Lane Celiac mechanism Gingerol
Gliadin -> tight junctions Transepithelial passage -> tTG2 deamidation ZO-1/occludin up
HLA-DQ2/DQ8 -> TH1 Anti-gliadin, anti-tTG2 -> NF-kB Enterocyte NF-kB -40%
IL-15 -> IEL -> NKG2D Enterocyte apoptosis -> villous atrophy IL-15 -30%, IEL -25%
Dysbiosis (active CD) LPS -> NF-kB -> IL-15 -> IEL hyperactivity Microbiome (1.19g sugar)
GIMBER = sugary dysbiosis for celiacs.
35g sugar/100ml -> dysbiosis -> LPS -> enterocyte NF-kB -> IL-15 up -> IEL hyperactivation -> celiac more reactive to diet deviations + weakened microbiome (already altered in active CD).
INTI: 1.19g of sugar per 100ml. INTI is naturally gluten-free. Supported microbiome. Enterocyte NF-kB -40%.
Medical note: The only treatment for celiac disease is a strict gluten-free diet (GFS) for life. INTI contributes additionally via NF-kB/IL-15 and support of the microbiome -- but in no way allows gluten deviations to be tolerated. Refractory celiac disease (non-response to RSG) requires specialized assessment (endoscopy, duodenal biopsies, IEL phenotyping). INTI is naturally gluten-free (verified on the INTI label).
Why is celiac so often undiagnosed?

Because 70-80% of celiac patients do not have the classic symptoms (diarrhea, malabsorption, digestion-ginger ginger-rapid-digestion-2026">bloating-irritable-colon">bloating). Silent or atypical forms dominate: unexplained iron deficiency anemia (iron malabsorption), premature osteoporosis (calcium/D malabsorption), infertility, peripheral neuropathy, dermatitis herpetiformis, depression. Screening is done by anti-tTG IgA + total IgA (to exclude an IgA deficiency which would distort the result). Confirmation = duodenal biopsies (Marsh III villous atrophy). HLA-DQ2/DQ8 negative = almost certain exclusion of celiac disease.

NRTI: Enterocyte anti-IL-15, naturally gluten-free

1.19g of sugar per 100ml | Gluten free | Enterocyte NF-kB -40% | IL-15 -30%

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