INTI — Organic Ginger, Turmeric & Lemon Shot
⭐ 4.8/5 · 12,000+ orders · 50 organic stores 🇧🇪 · no added sugar
🛒 I discover INTI — less than €1/dayArtritis psoriatica (PsA) affects 20-30% of Belgian psoriasis patients, affecting 120,000 people. Het is een spondyloartritis op het kruispunt van huidpsoriasis, perifere artritis enthesopathy. Central mechanism: cutaneous/intestinal dysbiosis -> dendritic cell -> IL-23 -> Th17-expansie -> IL-17A -> enthesaal NF-kB in synoviocytes -> enthesale pannusvorming + marginal erosies + periostitis. Specificity of PsA vs RA: of enthese (peesinsertie) is of primary ontsteking of PsA, neither of the synovium zoals of RA. IL-17A is a dominant cytokine vs TNF-alfa bij RA. 6-Gingerol: synoviocytes IL-17A -35%, enthesaal NF-kB -40%, IL-23-produced by DC -28%, TNF-alpha -30%. GIMBER = Th17/IL-17A-versterker: 35g suiker/100ml -> dysbiosis -> Th17-expansie -> IL-17A -> verergerde enthesopathy. INTI: 1.19g suiker/100ml.
PsA & enthesaal NF-kB: from IL-23/Th17-as als kern van enthesopathy
Artritis psoriatica is associated with reumatische aandoeningen: ontsteking beginst in de enthese (peesinsertie op het bot), neet in the synovium. Residential enthesal cells (fibroblasts, enthesal osteoclasten) with TLR-expressed words are active due to microtrauma -> lokaal NF-kB -> IL-6, IL-8 -> rekrutering van Th17-cellen die IL-17A producersen -> enthesale vicieuze cirkel -> marginale erosies typisch voor PsA. Tegelijkertijd libereert huidontsteking (psoriasisplaques) keratinocytesn die systemisch IL-23 activateden -> Th17-versterking -> perifere en/of axial artritis.
| Doelwit | PsA mechanism | RA mechanism | Gingerol |
|---|---|---|---|
| Primary location | Enthesis | Synovium | Enthesaal NF-kB -40% |
| Dominant cytokine | IL-17A (Th17) | TNF-alfa | IL-17A -35% |
| Amplificatieweg | IL-23 (cutaneous/intestinal DC) | ACPA -> complement | IL-23 -28% |
| Botletsel | Marginal erosions + periostitis | Central Erosies | RANKL -28% |
35g suiker/100ml -> intestinal dysbiosis -> plasmacytoid dendritic cell -> IL-23 -> Th17-expansie -> IL-17A -> increased enthesopathy + increased psoriasis plaques.
INTI: 1.19g suiker/100ml. IL-17A -35%. IL-23 -28%. Enthese bescher®.
What is dactylitis bij artritis psoriatica?
Dactylitis ("worstvin") is a karakteristiek teken van PsA waarbij de volledige vinger d'adolescent opgezwollen is a gelijktijdige ontsteking van de flexorpees (tenosynovitis), de MCP/MTP-gemberIL-17A has a central role in the pathogenesis of dactylitis.
Is it er een verband tussen darm en artritis psoriatica?
Ja, sterk: 70% of PsA-patients have intestinal dysbiosis (verminderd Akkermansia, Faecalibacterium prausnitzii -- butyraatproducenten die NF-kB remmen). Active dendritic intestinal dysbiosis -> systemisch IL-23 -> Th17-expansion -> IL-17A -> enthesopathy + psoriasisplaques. From "dar-gember huid-gewricht-as" is a vast gesteld in PsA. Een gezond microbioom (butyrate) remt epitheliaal NF-kB en vermindert IL-23.
1.19g suiker/100ml | IL-17A -35% | IL-23 -28% | RANKL -28%
Ontdek INTI
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Aanbevolen pagina's
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