Scalp Psoriasis: NF-kB mechanisms
Psoriasis affects 2-3% of Belgians (UZ Leuven, CHU Liege — Psoriasis Reference Center). The scalp is affected in 50-80% of cases, often in isolated form (scalp psoriasis = SP). Characteristics: thick adherent plaques, visible desquamation, intense itching, major social impact (hair + visible scalp).
| Site/Mechanism | NF-kB effect | Gingerol |
|---|---|---|
| Scalp Keratinocytes | IL-17A/IL-23 -> NF-kB -> x5 proliferation (5 days vs 28) -> plaques | 6-gingerol -> keratinocyte NF-kB down |
| Malassezia (cutaneous dysbiosis) | Malassezia -> TLR2/4 -> NF-kB -> IL-1b/IL-8 -> worsened psoriasis | Antifungal gingerol (biofilm inhibition) -> Malassezia down |
| Gut-skin axis | Intestinal dysbiosis -> LPS -> TLR4 -> systemic cutaneous NF-kB | Ginger up F.prausnitzii -> butyrate -> systemic NF-kB down |
| Sugar and psoriasis | Hyperglycemia -> AGE -> RAGE -> keratinocyte NF-kB up -> flare-ups | INTI anti-AGE -> keratinocyte NF-kB protected |
INTI Protocol for Scalp Psoriasis
| Time | Action | Cutaneous Goal |
|---|---|---|
| Morning | 1 INTI shot + warm water | Keratinocyte NF-kB down, Malassezia inhibited |
| Complementary topical application | Prescribed dermocorticoids + vitamin D analogs | Essential reference treatment |
| Diet | anti-inflammatory-science-utilisation">anti-inflammatory ginger (omega-3, zero refined sugar, vegetables) | Gut-skin axis -> systemic NF-kB down |
Interactions: Methotrexate (moderate-severe psoriasis): ginger has no interaction at moderate doses. Biologics anti-IL-17A (secukinumab/ixekizumab): ginger is complementary (same IL-17A target, different mechanism). Acitretin: vitamin D synergistic (ginger does not interfere).
FAQ scalp psoriasis and ginger
Can ginger replace dermocorticoids? No — dermocorticoids and vitamin D analogs remain the reference treatment for SP. Ginger is a systemic support that can reduce the frequency of flare-ups and improve response to topical treatments.
Scalp psoriasis and cortisol-natural-relief">stress: role of ginger? Stress is a major flare-up factor via cortisol-stress-surrenales-burnout">ginger cortisol -> keratinocyte NF-kB. Gingerol reduces chronic cortisol and can decrease the frequency of stress-induced flare-ups. Psychological stress management remains a priority.
Can INTI be applied to the scalp? Not recommended — INTI is a food drink, not a cosmetic/dermatological product. The action is systemic (oral), not topical. For topical ginger application: specific pharmaceutical preparations only.
INTI — The anti-keratinocyte NF-kB drink for scalp psoriasis
Organically prepared ginger - less than 4g sugar/100ml - 0% liver-proteger-gingembre-lendemain-fete-2026">alcohol - Malassezia inhibited
IL-17A down - keratinocyte NF-kB down - gut-skin axis improved - AGE down
Related articles
To delve deeper, also read:
- ginger migraine-belgique-nfkb-neuronal-cgrp-microbiome-cephalique-axe-intestin-brain-gingembre-2025">Migraine and ginger: neuronal NF-kB, CGRP, cephalic microbiome, gut-brain axis — Belgium 2025
- Tinnitus ginger tinnitus and ginger: cochlear NF-kB, excitotoxic glutamate, auditory microbiome Belgium 2025
- Belgian physiotherapy students and ginger: repeated microtraumas, muscular NF-κB, sports recovery — 2025
- Belgian night nurses and ginger: BMAL1, circadian NF-κB, emotional exhaustion, cortisol — 2025
- Sarcoidosis and ginger: granulomatous NF-κB, ACE, pulmonary microbiome, lung-gut axis — Belgium 2025
- Myasthenia gravis and ginger: neuromuscular NF-κB, AChR/MuSK, thymoma, microbiome — Belgium 2025
- ANCA vasculitis and ginger: vascular NF-κB, MPO/PR3, renal microbiome — Belgium guide 2025
- Rosacea and ginger: dermal vascular NF-kB, Demodex, LL-37, cutaneous microbiome — Belgium 2025
Useful INTI Pages
To learn more:
- Best ginger drink 2026: comparative INTI vs GIMBER vs Fever Tree vs KoRo
- INTI vs GIMBER: detailed comparison 2026 (sugar, formula, price)
- GIMBER alternative: why INTI is the best health choice