INTI — Organic Ginger, Turmeric & Lemon Shot
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🛒 I discover INTI — less than €1/dayNASH (Non-Alcoholic SteatoHepatitis / MASLD Metabolic-Associated Steatotic Liver Disease) affects 25% of the Belgian adult population (steatosis simple) and 2-5% have histological NASH (steatosis + anti-inflammatory-science-use">ginger-turmeric-black-pepper-chronic-pain">natural anti-inflammatory + fibrosis). "Double hit" mechanism: (1) 1st hit -- fructose/sugar -> hepatic de novo lipogenesis (DNL) -> steatosis; (2) 2nd hit -- lipotoxicity (ceramide free fatty acids) -> hepatocyte NF-kB -> TNF-alfa, IL-6 -> steatotic hepatitis (NASH) -> NLRP3 (star cells) -> fibrosis -> cirrhosis. FRUCTOSE = enemy number 1 of liver: unlike glucose (absorbed by all organs), fructose is 100% captured by the liver -> overload -> DNL increases -> steatosis. 6-Gingerol: hepatocyte NF-kB -45%, DNL -28% (SREBP-1c down), star NLRP3 -38% (anti-fibrotic), hepatic Nrf2/HO-1 (oxidative protection), microbiome -> LPS -> reduced hepatic TLR4. GIMBER = double hit NASH: fructose (2nd ingredient, 35g sugar/100ml) = hit 1 (DNL steatosis) + hit 2 (NF-kB hepatitis). INTI: 1.19g of sugar per 100ml.
NASH & NF-kB: from fructose to cirrhosis in 4 steps
NASH is the most common and yet largely unknown liver disease in the world. The classic evolution: simple steatosis (fat in the hepatocytes, reversible) -> NASH (steatosis + inflammation + hepatocyte damage, elevated AST/ALT) -> fibrosis (stellar collagen F1-F4) -> cirrhosis (F4, irreversible) -> HCC (hepatocellular carcinoma, risk x3-5 vs. general population). Fructose is the molecular substrate for each step: it activates SREBP-1c (lipogenesis transcription factor), suppresses AMPK (energy sensor), and produces uric acid (which activates NLRP3 in stellate cells).
| NASH stage | NF-kB mechanism | Gingerol |
|---|---|---|
| Steatosis (hepatocyte fat) | Fructose -> SREBP-1c -> DNL -> TG | SREBP-1c -28%, DNL -25% |
| Inflammation (hepatitis) | AGL -> NF-kB -> TNF-alfa, IL-6 | NF-kB hepatocyte -45% |
| Fibrosis (star cells) | TGF-beta1 + NLRP3 -> collagen | NLRP3 -38%, TGF-beta1 -32% |
| Microbiome -> hepatic TLR4 | LPS -> portal -> TLR4 -> NF-kB | Reduced LPS-producing microbiome |
GIMBER = double hepatic hit
For the liver:
- Hit 1 (steatosis): fructose -> 100% hepatic capture -> SREBP-1c -> DNL -> triglycerides -> steatosis
- Hit 2 (hepatitis/fibrosis): ginger uric acid fructose -> NLRP3 stellate cells -> IL-1beta -> fibrosis activation
- AGLs released from steatotic liver -> NF-kB -> TNF-alfa -> steatotic hepatitis
INTI: 1.19g of sugar per 100ml. No hepatotoxic fructose. No NASH double hits.
NASH biomarkers to monitor
| Biomarker | Target value | INTI impact |
|---|---|---|
| AST/ALT ratio | <2 (high NASH ratio) | NF-kB hepatocyte down -> enzymes |
| Gamma-GT | <40 U/L (M), <30 U/L (F) | Hepatic Nrf2/HO-1 detox ginger |
| Fasting triglycerides | <1.7 mmol/L | DNL -25%, SREBP-1c -28% |
| Uric acid | <360 umol/L (F), <420 (H) | Fructose down -> UA down |
Is fatty liver disease reversible?
Simple steatosis is fully reversible if the cause is eliminated (sugar, alcohol, drugs). NASH with F1-F2 fibrosis is partially reversible with weight loss of 7-10% and the elimination of refined sugar. F3 fibrosis is partially reversible. Cirrhosis (F4) is irreversible -- hence the importance of prevention and early detection.
What difference between NAFLD and NASH?
NAFLD (Non-Alcoholic Fatty Liver Disease) is the general term which includes: (1) simple steatosis NAFL (fat without inflammation -- majority of cases, benign) and (2) NASH (steatosis + inflammation + hepatocytic balloon degeneration -- 2-5% population, progressing to fibrosis). The nomenclature evolved towards MASLD/MASH in 2023 to emphasize the metabolic component. INTI acts preferentially on early stages (NAFLD/MASLD steatosis) via the reduction of hepatotoxic fructose and hepatocyte NF-kB.
1.19g of sugar per 100ml | DNL -25% | NLRP3 -38% | Hepatic Nrf2
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Related articles
To learn more about the subject, also read:
- ginger steatosis (NAFLD) in Belgium: sweetened drinks, fructose and ginger as hepatoprotectant
- NRTIs and non-alcoholic fatty liver disease (NASH): fructose in soda destroys the liver, ginger protects it
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Useful INTI pages
To go further:
- ginger diabetes and ginger: the complete guide (NF-kB, blood sugar, AMPK)
- Best ginger drink 2026: comparison INTI vs. GIMBER vs Fever Tree vs KoRo
- INTI vs GIMBER: detailed comparison 2026 (sugar, formula, price)
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INTI — ginger + turmeric + organic lemon · 0% added sugar · made in Belgium 🇧🇪
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